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Index > Protein center > Cyp27a1(Gene name) > Rat
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  • Cyp27a1 (Gene name),
  • Sterol 26-hydroxylase, mitochondrial (Protein name ),  CP27A_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Cyp27a1(Cyp27);
    Protein name:
    Sterol 26-hydroxylase, mitochondrial;
    Alternative:
    Cytochrome P-450C27/25;5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase;Sterol 27-hydroxylase;Cytochrome P450 27;Vitamin D(3) 25-hydroxylase;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.
    Subcellular Location:
    Mitochondrion membrane
    Protein Attributes:
    Sequence length:
    533
    Sequence:
    50:
    MAVLSRMRLR | WALLDTRVMG | HGLCPQGARA | KAAIPAALRD | HESTEGPGTG | 
    100:
    QDRPRLRSLA | ELPGPGTLRF | LFQLFLRGYV | LHLHELQALN | KAKYGPMWTT | 
    150:
    TFGTRTNVNL | ASAPLLEQVM | RQEGKYPIRD | SMEQWKEHRD | HKGLSYGIFI | 
    200:
    TQGQQWYHLR | HSLNQRMLKP | AEAALYTDAL | NEVISDFIAR | LDQVRTESAS | 
    250:
    GDQVPDVAHL | LYHLALEAIC | YILFEKRVGC | LEPSIPEDTA | TFIRSVGLMF | 
    300:
    KNSVYVTFLP | KWSRPLLPFW | KRYMNNWDNI | FSFGEKMIHQ | KVQEIEAQLQ | 
    350:
    AAGPDGVQVS | GYLHFLLTKE | LLSPQETVGT | FPELILAGVD | TTSNTLTWAL | 
    400:
    YHLSKNPEIQ | EALHKEVTGV | VPFGKVPQNK | DFAHMPLLKA | VIKETLRLYP | 
    450:
    VVPTNSRIIT | EKETEINGFL | FPKNTQFVLC | HYVVSRDPSV | FPEPESFQPH | 
    500:
    RWLRKREDDN | SGIQHPFGSV | PFGYGVRSCL | GRRIAELEMQ | LLLSRLIQKY | 
    533:
    EVVLSPGMGE | VKSVSRIVLV | PSKKVSLRFL | QRQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    E10323h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    E10323m
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    E10323r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Sterol 26-hydroxylase, mitochondrial
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    U10323h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sterol 26-hydroxylase, mitochondrial
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    U10323r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    U10323m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    P10323Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    P10323Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sterol 26-hydroxylase, mitochondrial
    Cat.:
    P10323Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sterol 26-hydroxylase, mitochondrial
    Monoclonal Antibody for Rat Sterol 26-hydroxylase, mitochondrial
    Monoclonal Antibody for Rat Sterol 26-hydroxylase, mitochondrial
    Monoclonal Antibody for Rat Sterol 26-hydroxylase, mitochondrial
    Monoclonal Antibody for Rat Sterol 26-hydroxylase, mitochondrial
    Protein for Rat Sterol 26-hydroxylase, mitochondrial
    Protein for Rat Sterol 26-hydroxylase, mitochondrial
    Protein for Rat Sterol 26-hydroxylase, mitochondrial
    Protein for Rat Sterol 26-hydroxylase, mitochondrial

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    References
    1. 1.
      "Molecular cloning of cDNA for vitamin D3 25-hydroxylase from rat liver mitochondria."
      Usui E. , Noshiro M. , Okuda K.
      FEBS Lett.262:135-138(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];PROTEIN SEQUENCE OF 33-37
      strain: Wistar.
      tissue: Liver.
    2. 2.
      "A cDNA encoding a rat mitochondrial cytochrome P450 catalyzing both the 26-hydroxylation of cholesterol and 25-hydroxylation of vitamin D3: gonadotropic regulation of the cognate mRNA in ovaries."
      Su P. , Rennert H. , Shayiq R.M. , Yamamoto R. , Zheng Y.-M. , Addya S. , Strauss J.F. III , Avadhani N.G.
      DNA Cell Biol.9:657-667(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    3. 3.
      "Sequence complementarity between the 5'-terminal regions of mRNAs for rat mitochondrial cytochrome P-450c27/25 and a growth hormone-inducible serine protease inhibitor. A possible gene overlap."
      Shayiq R.M. , Avadhani N.G.
      J. Biol. Chem.267:2421-2428(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    4. 4.
      "Localization of a transcription promoter within the second exon of the cytochrome P-450c27/25 gene for the expression of the major species of two-kilobase mRNA."
      Mullick J. , Addya S. , Sucharov C. , Avadhani N.G.
      Biochemistry34:13729-13742(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
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